KY 19382

KY 19382 is an inhibitor of the protein-protein interaction between CXXC-type zinc finger protein 5 (CF5) and Dishevelled (Dvl, IC50 = 19 nM). It is also an inhibitor of glycogen synthase kinase 3beta (GSK3beta, IC50 = 10 nM). KY 19382 (100 nM) increases expression of the mRNA encoding Wnt1-inducible signaling pathway protein 1 (WISP-1) and Axin2, markers of Wnt pathway activation, in ATDC-5 chondrogenic cells. It increases nuclear and cytosolic levels of beta-catenin in ATDC-5 cells when used at a concentration of 100 nM. KY 19382 (0.1 mg/kg per day) increases bone plate growth and tibia length in adolescent mice.Formal Name: 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one. CAS Number: 2226664-93-1. Molecular Formula: C17H11Cl2N3O2. Formula Weight: 360.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C1NC2=C(C1=C3NC4=C(C3=NOC)C=CC=C4)C=C(Cl)C(Cl)=C2. InChi Code: InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,20H,1H3,(H,21,23). InChi Key: PROTUMHDKVZVBW-UHFFFAOYSA-N.