KOTX1

An ALDH1A3 inhibitor (IC50 = 5.14 nM), potentiates glucose-induced insulin secretion from pancreatic islets isolated from patients with type 2 diabetes at 10 µM, decreases plasma insulin levels and reduces blood glucose levels in an IPGTT in diabetic db/db male mice at 40 mg/kg per day, decreases blood glucose levels and increases plasma insulin levels in a mouse model of high-fat diet-induced obesity at 270 ppm in the diet. Formulation: A solid. InChI: InChI=1S/C17H16FN3O2/c1-2-10-9-19-6-5-12(10)17(23)21-15-7-11-3-4-16(22)20-14(11)8-13(15)18/h5-9H,2-4H2,1H3,(H,20,22)(H,21,23). InChIKey: QJJWNFKDFKNPEV-UHFFFAOYSA-N. SMILES: FC1=C(C=C2C(NC(CC2)=O)=C1)NC(C3=C(CC)C=NC=C3)=O