Kisspeptin-234 (trifluoroacetate salt)

Kisspeptin-234 is a peptide antagonist of the kisspeptin receptor, previously known as G protein-coupled receptor 54 (GPR54). It inhibits kisspeptin-10-induced inositol phosphate production in CHO cells expressing the human kisspeptin receptor (IC50 = 7 nM) and kisspeptin-10-induced firing of isolated mouse gonadotropin-releasing hormone (GnRH) neurons. In vivo, kisspeptin-234 inhibits pulsatile GnRH secretion in pubertal female rhesus monkeys. It also inhibits kisspeptin-10-induced luteinizing hormone secretion in adult male rats and mice.Formal Name: (S)-N1-((6S,9R,15S)-9-((1H-indol-3-yl)methyl)-1-amino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-15-benzyl-1-imino-8,11,14,17-tetraoxo-2,7,10,13,16-pentaazaoctadecan-18-yl)-2-((S)-2-((S)-2-((R)-2-acetamidopropanamido)-4-amino-4-oxobutanamido)-3-(1H-indol-3-yl)propanamido)succinamide, 2,2,2-trifluoroacetic acid. CAS Number: 1848962-29-7. Synonyms: Kp-234. Molecular Formula: C63H78N18O13 . XCF3COOH. Formula Weight: 1295.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly Soluble, DMSO: Slightly Soluble. SMILES: CC(N[C@H](C)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(NCC(N[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C63H78N18O13.C2HF3O2/c1-34(74-35(2)82)56(88)79-50(29-52(65)84)62(94)80-48(27-39-31-71-43-21-12-10-19-41(39)43)61(93)81-49(28-51(64)83)58(90)73-32-53(85)75-46(25-37-16-7-4-8-17-37)57(89)72-33-54(86)76-47(26-38-30-70-42-20-11-9-18-40(38)42)60(92)77-44(22-13-23-69-63(67)68)59(91)78-45(55(66)87)24-36-14-5-3-6-15-36,3-2(4,5)1(6)7/h3-12,14-21,30-31,34,44-50,70-71H,13,22-29,32-33H2,1-2H3,(H2,64,83)(H2,65,84)(H2,66,87)(H,72,89)(H,73,90)(H,74,82)(H,75,85)(H,76,86)(H,77,92)(H,78,91)(H,79,88)(H,80,94)(H,81,93)(H4,67,68,69),(H,6,7)/t34-,44+,45+,46+,47-,48+,49+,50+,/m1./s1. InChi Key: XYUGIYOAGFFAEE-VIJDQBLHSA-N.