Kibdelone C

Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.Formal Name: (10S,12S,13R)-4-chloro-6,7,10,11,12,13-hexahydro-5,10,12,13,15,16-hexahydroxy-8-methoxy-2-methyl-3-propyl-2H-[1]benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,14-dione. CAS Number: 934464-79-6. Synonyms: (+)-Kibdelone C. Molecular Formula: C29H28ClNO10. Formula Weight: 586.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: O=C1N(C)C(CCC)=C(Cl)C2=C1C(O)=C(C3=C(O)C(C4=O)=C(C(OC)=C3CC5)OC6=C4[C@@H](O)[C@@H](O)C[C@@H]6O)C5=C2O. InChi Code: InChI=1S/C29H28ClNO10/c1-4-5-11-20(30)16-17(29(39)31(11)2)23(36)14-9(21(16)34)6-7-10-15(14)24(37)19-25(38)18-22(35)12(32)8-13(33)27(18)41-28(19)26(10)40-3/h12-13,22,32-37H,4-8H2,1-3H3/t12-,13-,22-/m0/s1. InChi Key: NEZGGHIIKFHZCZ-MZFXBISCSA-N. Origin: Bacterium/Kibdelosporangium sp..