K114

A fluorescent probe for the detection of amyloids, pH-dependent ex/em maxima = 370/450 nm, respectively, at pH 8.5, pH-dependent ex/em maxima = 420/520 nm, respectively, at pH 10.5, demonstrates increased fluorescence intensity in the presence of Aß40 fibrils, displays fiber-dependent excitation/emission maxima for silk moth (B. mori) silk, Chilean rose tarantula (G. rosea) web, and 5XFAD mouse brain amyloid fibers, has been used to detect amyloid plaques in postmortem hippocampus from patients with Alzheimer's disease.. Formulation: A solid. InChI: InChI=1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+. InChIKey: OXPHQQMZTXMEGO-RJTULKDBSA-N. SMILES: OC(C=C1)=CC=C1/C=C/C2=C(C=C(C=C2)/C=C/C3=CC=C(C=C3)O)Br