K-252b

Description: K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor. It is effective in inhibiting extracellular kinases in cultured cells due to its inability to freely cross the cell membrane. Target: PKC. Smiles: CC12OC(CC1(O)C(O)=O)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13. References: Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986).