JNJ-A07

JNJ-A07 is an inhibitor of the protein-protein interaction between dengue virus non-structural protein 3 (NS3) and NS4B (EC50 = 35 nM in a pull-down assay). It inhibits replication of 21 dengue virus clinical isolates in Vero E6 cells (EC50s = 0.07-0.3 nM). JNJ-A07 reduces dengue virus RNA levels in mosquitos (A. aegypti) when fed blood meals containing it at a concentration of at 2 µM. It decreases blood dengue virus RNA levels and increases survival in a mouse model of dengue virus infection when administered at doses of 1, 3, 10, or 30 mg/kg. SMILES O=C(N1C2=CC(OC(F)(F)F)=CC=C2CC1)C(NC3=CC(OCCCC(O)=O)=CC(OC)=C3)C4=CC=C(Cl)C=C4 InChi Code InChI=1S/C28H26ClF3N2O6/c1-38-22-13-20(14-23(15-22)39-12-2-3-25(35)36)33-26(18-4-7-19(29)8-5-18)27(37)34-11-10-17-6-9-21(16-24(17)34)40-28(30,31)32/h4-9,13-16,26,33H,2-3,10-12H2,1H3,(H,35,36) InChi Key WUBVXTOLZKVNEG-UHFFFAOYSA-N