JBSNF-000088

JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT, IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively). It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO). It also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively.Formal Name: 6-methoxy-3-pyridinecarboxamide. CAS Number: 7150-23-4. Synonyms: 6-Methoxynicotinamide, NSC 70628. Molecular Formula: C7H8N2O2. Formula Weight: 152.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 5mg/mL, DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL, Ethanol: 1mg/mL. lambdamax: 240, 273 nm. SMILES: NC(C1=CC=C(OC)N=C1)=O. InChi Code: InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10). InChi Key: KXDSMFBEVSJYRF-UHFFFAOYSA-N.