J-147

Description: J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy. Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase. Smiles: COc1cccc(\C=N\N(C(=O)C(F)(F)F)c2ccc(C)cc2C)c1. References: Lapchak PA, et al. J Neurol Neurophysiol. 2013 Aug,4(3). pii: 158.