ISX-9

ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. At 2.5-20 µM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression. ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.Formal Name: N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide. CAS Number: 832115-62-5. Synonyms: Isoxazole 9, Neuronal Differentiation Inducer III. Molecular Formula: C11H10N2O2S. Formula Weight: 234.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 294 nm. SMILES: O=C(NC1CC1)C2=NOC(C3=CC=CS3)=C2. InChi Code: InChI=1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14). InChi Key: SYENTKHGMVKGAQ-UHFFFAOYSA-N.