Isotretinoin

Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Cay-11017) and has diverse biological activities. It increases the doubling time and transcription of retinoic acid receptor beta (RARbeta) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 µM. Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 µM). It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 µM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-gamma and IL-10 in allografts in chronic Fisher344?Lewis transplant mice, an allograft nephropathy model. It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg. Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.Formal Name: 13-cis-retinoic acid. CAS Number: 4759-48-2. Synonyms: AGN 190013, 13(Z)-Retinoic Acid, 13-cis-Vitamin A Acid. Molecular Formula: C20H28O2. Formula Weight: 300.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 1 mg/ml. lambdamax: 242, 356 nm. SMILES: CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(O)=O)C(C)(C)CCC1. InChi Code: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-. InChi Key: SHGAZHPCJJPHSC-XFYACQKRSA-N.