Isorhamnetin-3-O-beta-D-Glucoside

Isorhamnetin-3-O-beta-D-glucoside is a flavonoid glycoside that has been found in T. capensis and has diverse biological activities. It scavenges DPPH (Cay-14805) and ABTS (Cay-27317) radicals in cell-free assays (IC50s = 3.16 and 44.93 µg/ml, respectively). Isorhamnetin-3-O-beta-glucoside inhibits H. contortus egg hatching and larval development (EC50s = 431.5 and 55.61 µg/ml, respectively) and induces lethality in C. elegans (EC50 = 342 µg/ml). It inhibits rat lens aldose reductase (IC50 = 0.75 µg/ml) and reduces sorbitol accumulation in lenses, red blood cells, and sciatic nerve in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104).Formal Name: 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 5041-82-7. Synonyms: 3'-O-Methylquercetin 3'-glucoside. Molecular Formula: C22H22O12. Formula Weight: 478.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 255, 360 nm. SMILES: O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=C(C2=CC(OC)=C(C=C2)O)OC3=CC(O)=C4)C3=C4O. InChi Code: InChI=1S/C22H22O12/c1-31-12-4-8(2-3-10(12)25)20-21(17(28)15-11(26)5-9(24)6-13(15)32-20)34-22-19(30)18(29)16(27)14(7-23)33-22/h2-6,14,16,18-19,22-27,29-30H,7H2,1H3/t14-,16-,18+,19-,22+/m1/s1. InChi Key: CQLRUIIRRZYHHS-LFXZADKFSA-N. Origin: Plant/Ilex cornuta.