Isoforskolin

Isoforskolin is a naturally occurring diterpene originally isolated from the Indian coleus plant C. forskohlii. It demonstrates positive inotropic effects ex vivo in guinea pig atria (EC50 = 1.09 µM). In vivo, isoforskolin is antihypertensive, decreasing systolic blood pressure by 28 mmHg in spontaneously hypertensive rats when administered at 25 mg/kg per day, p.o. for 5 days. Pretreatment of rats with isoforskolin (10 mg/kg, i.p.) decreases LPS-induced lung injury by decreasing karyocyte, neutrophil count, and protein content in bronchoalveolar lavage fluid, and ameliorating LPS-induced lung morphological changes. Isoforskolin (1 mg/kg, i.p.) decreases mean arthritis index in a mouse model of Lyme arthritis induced by injection of B. burgdorferi basic membrane protein A (BmpA) into the tibiotarsal joint cavity. Isoforskolin also activates membranous mammalian adenylyl cyclase (AC) expressed in insect cells (EC50s = 0.8, 13.3, and 7.4 µM for AC1, AC2, and AC5, respectively).Formal Name: (3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one. CAS Number: 64657-21-2. Molecular Formula: C22H34O7. Formula Weight: 410.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, DMSO: Soluble. SMILES: O=C1C[C@@](C=C)(C)O[C@]2(C)[C@@H](O)[C@@H](OC(C)=O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@]21O. InChi Code: InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1. InChi Key: CLOQVZCSBYBUPB-KGGHGJDLSA-N. Origin: Plant/Coleus forskohlii.