IS20

A nonpeptide agonist of PKR1 and PAM of PKR2, increases intracellular calcium release and Akt phosphorylation in PKR1-expressing CHO cells (EC50 = 44 nM), enhances prokineticin-induced ERK phosphorylation in PKR2-expressing CHO cells at 1 nM, increases survival, reduces cardiac lesion formation, improves cardiac function, and increases neovasculogenesis in a mouse model of myocardial infarction at 0.5 mg/kg, i.p.. SMILES: COC(C=C1)=CC=C1/C=C(C(NCC2=CN=CC=C2)=O)\NC(C3=CC=CC=C3)=O. InChi Code: InChI=1S/C23H21N3O3/c1-29-20-11-9-17(10-12-20)14-21(26-22(27)19-7-3-2-4-8-19)23(28)25-16-18-6-5-13-24-15-18/h2-15H,16H2,1H3,(H,25,28)(H,26,27)/b21-14-. InChi Key: KKDANILRTKQMGA-STZFKDTASA-N