Iromycin A

Iromycin A is a bacterial pyridone metabolite that inhibits nitric oxide synthase (NOS) activity, with selectivity for NOS III (endothelial NOS) over NOS I (neuronal NOS). Iromycin metabolites and derivatives block NADH oxidation in beef heart submitochondrial particles (IC50 = 0.461 µM for iromycin A).Formal Name: 6-[(2E,5E)-3,7-dimethyl-2,5-octadien-1-yl]-4-hydroxy-3-methyl-5-propyl-2(1H)-pyridinone. CAS Number: 213137-53-2. Synonyms: NK 26588. Molecular Formula: C19H29NO2. Formula Weight: 303.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Slightly Soluble. SMILES: CC1=C(O)C(CCC)=C(C/C=C(C)/C/C=C/C(C)C)NC1=O. InChi Code: InChI=1S/C19H29NO2/c1-6-8-16-17(20-19(22)15(5)18(16)21)12-11-14(4)10-7-9-13(2)3/h7,9,11,13H,6,8,10,12H2,1-5H3,(H2,20,21,22)/b9-7+,14-11+. InChi Key: HVAVEUHAOCVIPN-DTCTWCMCSA-N. Origin: Bacterium/Streptomyces bottropensis.