Irisflorentin

Description: 1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Target: NO Synthase. Smiles: COc1cc(cc(OC)c1OC)-c1coc2cc3OCOc3c(OC)c2c1=O. References: Chen Y M , Liu S P , Lin H L , et al. Irisflorentin improves alpha-synuclein accumulation and attenuates 6-OHDA-induced dopaminergic neuron degeneration, implication for Parkinson's disease therapy[J]. BioMedicine, 2015, 5(1):4.