Irigenin

Description: Irigenin mediates its antimetastatic effect by specifically and selectively blocking the alpha9beta1 and alpha4beta1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enhancing the expression of pro-apoptotic molecules in gastric cancer cells and has anti-cancer effects. Target: Integrin, NF-kappaB. Smiles: COc1cc(cc(O)c1OC)-c1coc2cc(O)c(OC)c(O)c2c1=O. References: Kwang Seok Ahn, et al. Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E2 production in murine macrophage RAW 264.7 cells. 2006, 78(20): 2336-2342.