IQ-3

Description: IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-kappaB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 µM, also inhibits TNF-alpha and IL-6 production in vitro. Target: JNK. Smiles: O=C(ON=C1c2ccccc2-c2nc3ccccc3nc12)c1ccco1. References: Schepetkin I A , Kirpotina L N , Khlebnikov A I , et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors[J]. Molecular Pharmacology, 2012, 81(6):832-845.