Indoxyl Sulfate (potassium salt)

Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan (Cay-29600). It is formed via sulfation of indoxyl, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.Formal Name: 1H-indol-3-ol, 3-(hydrogen sulfate), monopotassium salt. CAS Number: 2642-37-7. Molecular Formula: C8H6NO4S . K. Formula Weight: 251.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 221, 281 nm. SMILES: [O-]S(OC1=CNC2=CC=CC=C21)(=O)=O.[K+]. InChi Code: InChI=1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8,/h1-5,9H,(H,10,11,12),/q,+1/p-1. InChi Key: MDAWATNFDJIBBD-UHFFFAOYSA-M.