(-)-Indolactam V

Description: (-)-Indolactam V, a potent PKC activator, exhibits binding affinities (Kis) of 3.36 nM and 1.03 µM for eta-CRD2 and gamma-CRD2, respectively, and dissociation constants (Kds) of 5.5 nM (eta-C1B), 7.7 nM (epsilon-C1B), 8.3 nM (delta-C1B), 18.9 nM (beta-C1A-long), 20.8 nM (alpha-C1A-long), 137 nM (beta-C1B), 138 nM (gamma-C1A), and 213 nM (gamma-C1B), also demonstrating antitumor activity. Target: PKC. Smiles: CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23