IN-1130

Description: IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 µM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein and p38alpha mitogen-activated protein kinase. Target: ALK. Smiles: Cc1cccc(n1)-c1nc(Cc2cccc(c2)C(N)=O)[nH]c1-c1ccc2nccnc2c1. References: Moon JA, et al. IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int. 2006 Oct,70(7):1234-43.