IMS 2186

IMS 2186 is an anti-choroidal neovascularization agent. It inhibits proliferation of NIH3T3 mouse and IMR-90 human fibroblasts (IC50s = 0.5-3 µM), as well as in a panel of eight human cancer cell lines, including ovarian, lung, colon, and pancreatic cancer cells (IC50s = 0.3-3 µM). IMS 2186 (10 µM) decreases migration of THP-1 macrophages in wound healing and chamber assays. Subcutaneous administration of IMS 2186 (20 µg/animal) inhibits VEGF-induced blood vessel formation in a MatrigelTM plug assay in mice. It reduces ocular leakage, as well as cellular proliferation and infiltration in a rat model of laser-induced choroidal neovascularization when administered intravitreally at a dose of 100 µg/eye.Formal Name: (3E)-2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-4H-1-benzopyran-4-one. CAS Number: 1031206-36-6. Molecular Formula: C18H16O4. Formula Weight: 296.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 5 mg/ml, Ethanol: 1 mg/ml. SMILES: CC1=CC=C(OC/C(C2=O)=C\C3=CC=C(OC)C(O)=C3)C2=C1. InChi Code: InChI=1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+. InChi Key: BZCADTHMZLYKAR-MDWZMJQESA-N.