IM-54

IM-54 is an indolylmaleimide derivative which, at 1 µM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase 1.Formal Name: 1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione. CAS Number: 861891-50-1. Molecular Formula: C19H23N3O2. Formula Weight: 325.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 1 mg/ml. lambdamax: 206, 227, 289, 404 nm. SMILES: CCCCCNC1=C(C(=O)N(C)C1=O)c1cn(C)c2ccccc12. InChi Code: InChI=1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)22(3)19(17)24)14-12-21(2)15-10-7-6-9-13(14)15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3. InChi Key: SGLOMINNEBLJFF-UHFFFAOYSA-N.