icFSP1 (trifluoroacetate salt)

icFSP1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1). It induces condensation and phase separation of FSP1 in cells when used at a concentration of 2.5 µM but does not inhibit FSP1 enzymatic activity in a cell-free assay (IC50 = > 30 µM). icFSP1 induces ferroptosis in HT-1080 fibrosarcoma cells in a concentration-dependent manner. In vivo, icFSP1 (50 mg/kg) decreases tumor volume and weight in a B16/F10 murine melanoma model using human FSP1-overexpressing, Gpx4-/-Fsp1-/- B16/F10 cells.Formal Name: 3,4,5-trimethoxy-N-[4-(2-methyl-4-oxo-3(4H)-quinazolinyl)phenyl]-benzeneacetamide, trifluoroacetate salt. Molecular Formula: C26H25N3O5 . CF3COOH. Formula Weight: 573.5. Purity: >98%. Formulation: (Request formulation change), A solid. lambdamax: 236 nm. SMILES: O=C1C2=C(N=C(C)N1C3=CC=C(NC(CC4=CC(OC)=C(C(OC)=C4)OC)=O)C=C3)C=CC=C2.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C26H25N3O5.C2HF3O2/c1-16-27-21-8-6-5-7-20(21)26(31)29(16)19-11-9-18(10-12-19)28-24(30)15-17-13-22(32-2)25(34-4)23(14-17)33-3,3-2(4,5)1(6)7/h5-14H,15H2,1-4H3,(H,28,30),(H,6,7). InChi Key: FSKUADANDUYANM-UHFFFAOYSA-N.