IACS-9571

Description: IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24, Kds: 31 nM and 14 nM for TRIM24 and BRPF1). Target: Epigenetic Reader Domain. Smiles: CN1C=2C(=CC(NS(=O)(=O)C3=CC(OC)=C(OC)C=C3)=C(OC4=CC(OCCCCN(C)C)=CC(OCCC)=C4)C2)N(C)C1=O. References: Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25,59(4):1440-54.