Hypotaurine

Hypotaurine is an endogenous inhibitory amino acid. It inhibits GABA uptake by mouse GABA transporter 1 (GAT1), GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 µM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 µM, respectively). Hypotaurine also inhibits GABA uptake by betaine/GABA transporter 1 (BGT1) in L-M(TK-) cells expressing the human transporter (IC50 = 380 µM). It inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 µM). It scavenges hypochlorous acid (HOCl) and hydroxyl, but not superoxide, radicals in cell-free assays. Hypotaurine (1 mM) protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death.Formal Name: 2-amino-ethanesulfinic acid. CAS Number: 300-84-5. Molecular Formula: C2H7NO2S. Formula Weight: 109.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: NCCS(O)=O. InChi Code: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5). InChi Key: VVIUBCNYACGLLV-UHFFFAOYSA-N.