Hypocrellin A

Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities. It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively). Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.Formal Name: 1-acetyl-2,3-dihydro-2,6,11-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-1H-cyclohepta[ghi]perylene-5,12-dione, stereoisomer. CAS Number: 77029-83-5. Molecular Formula: C30H26O10. Formula Weight: 546.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2mg/mL, DMSO: 3mg/mL, Ethanol: 0.3mg/mL. SMILES: COC1=C(CC(C)(O)C2C(C)=O)C3=C4C(C(OC)=CC(O)=C4C1=O)=C5C(OC)=CC(O)=C6C5=C3C2=C(OC)C6=O. InChi Code: InChI=1S/C30H26O10/c1-10(31)25-24-22-16-11(9-30(25,2)36)28(39-5)26(34)17-12(32)7-14(37-3)19(21(16)17)20-15(38-4)8-13(33)18(23(20)22)27(35)29(24)40-6/h7-8,25,32-33,36H,9H2,1-6H3. InChi Key: BQJKVFXDDMQLBE-UHFFFAOYSA-N. Origin: Fungus/Hypocrella bambusae.