Hyperforin . DCHA

Key constituent of St, John's wort, Shows properties of potential pharmacological interest, including anti-bacterial , anti-malarial , anti-inflammatory , anti-cancer and anti-angiogenic effects, Anti-depressant and anxiolytic compound, Specific activator of TRPC6 channels, Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate), Activator of the pregnane X receptor (PXR), Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism, Potential anti-Alzheimer compound, Potent SIRT1 (sirtuin1) and SIRT2 (sirtuin2) inhibitor. Isolated from St. John's wort (Hypericum perforatum).