Homatropine (hydrobromide)

Homatropine is an anticholinergic agent. It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 µM. Homatropine (1 µM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle. It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 µM, respectively). Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.Formal Name: alpha-hydroxy-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, monohydrobromide. CAS Number: 51-56-9. Synonyms: (±)-Homatropine. Molecular Formula: C16H21NO3 . HBr. Formula Weight: 356.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C(O)C1=CC=CC=C1)O[C@H]2C[C@H](N3C)CC[C@H]3C2.Br. InChi Code: InChI=1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11,/h2-6,12-15,18H,7-10H2,1H3,1H/t12-,13+,14+,15?,. InChi Key: DWSGTFTVBLXELC-RDYJJYPNSA-N.