HM03

HM03 is an inhibitor of the protein-protein interaction between the DNA excision repair protein ERCC-1 and the DNA repair endonuclease XPF (IC50 = 1.86 µM). It is also an inhibitor of D-alanine-D-alanine ligase B (DdlB, Ki = 218 µM for the E. coli enzyme). HM03 is active against E. coli and S. aureus (MICs = 64 and 32 µg/ml, respectively). It potentiates cytotoxicity induced by cisplatin (Cay-13119) in A549 lung and HCT116 colon cancer cells when used at a concentration of 100 µM.Formal Name: 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol. CAS Number: 500565-15-1. Molecular Formula: C26H27ClN4O2. Formula Weight: 463.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: ClC(C=CC1=C2NC3=CC=C(O)C(CN4CCN(CC4)C)=C3)=CC1=NC5=C2C=C(OC)C=C5. InChi Code: InChI=1S/C26H27ClN4O2/c1-30-9-11-31(12-10-30)16-17-13-19(4-8-25(17)32)28-26-21-6-3-18(27)14-24(21)29-23-7-5-20(33-2)15-22(23)26/h3-8,13-15,32H,9-12,16H2,1-2H3,(H,28,29). InChi Key: SUSDGTMJKOGWSZ-UHFFFAOYSA-N.