Hispidulin

Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities. It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607), and ADP (IC50s = 20, 4, and 13 µM, respectively). Hispidulin inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and bone marrow-derived macrophages (BMMs). In vivo, hispidulin (25 µg/kg) inhibits LPS-induced bone resorption in mice. It inhibits sphingosine kinase 1 (SPHK1) and induces ceramide accumulation and apoptosis in Caki-2 renal carcinoma cells in vitro and inhibits tumor growth in a Caki-2 mouse xenograft model. Pretreatment with hispidulin (40 mg/kg) reduces cognitive deficits in the Morris water maze induced by sevoflurane (Cay-23996) in aged rats. It also decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.Formal Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one. CAS Number: 1447-88-7. Synonyms: Dinatin, 6-Methoxyapigenin, NSC 122415. Molecular Formula: C16H12O6. Formula Weight: 300.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 218, 275, 336 nm. SMILES: OC1=C(OC)C(O)=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=C1. InChi Code: InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3. InChi Key: IHFBPDAQLQOCBX-UHFFFAOYSA-N. Origin: Plant/Salvia plebeia R. Br..