Hispidol

Description: Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease, inhibits TNF-alpha induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM. Target: TNF. Smiles: Oc1ccc(\C=C2/Oc3cc(O)ccc3C2=O)cc1. References: Kadayat TM, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017 Sep 8,137:575-597.