HIF-2alpha-IN-4

Description: HIF-2a translation inhibitor is a potent HIF-2alpha translation inhibitor with IC50=5 µM that inhibits constitutive and hypoxia-induced HIF-2alpha protein expression. Among them, HIF-2alpha-IN-4 associates the 5'UTR iron response element with oxygen sensing. Target: HIF/HIF Prolyl-Hydroxylase. Smiles: COC(=O)c1sccc1N\N=C(/C#N)S(C)(=O)=O