Hexanoyl Glycine

Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase. Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation. Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARalpha ligand Wy 14643 (Cay-70730).Formal Name: N-1-oxohexyl-glycine. CAS Number: 24003-67-6. Synonyms: NSC 224460. Molecular Formula: C8H15NO3. Formula Weight: 173.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: OC(CNC(CCCCC)=O)=O. InChi Code: InChI=1S/C8H15NO3/c1-2-3-4-5-7(10)9-6-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12). InChi Key: UPCKIPHSXMXJOX-UHFFFAOYSA-N.