Hesperidin

Hesperidin is a flavanone rutinoside first isolated from citrus peels. It is metabolized by intestinal bacteria to an aglycone form, hesperetin (Cay-10006084), which is thought to be more bioavailable due to reduced polarity that allows for increased cell permeability. At 100 µM, hesperidin has been shown to increase the cytotoxicity of doxorubicin (Cay-15007) on MCF-7 and HeLa cancer cells in vitro by inhibiting cell cycle progression and upregulating apoptosis. It also is reported to produce estrogenic effects, decreasing serum and hepatic lipid concentrations and reducing osteoporosis in ovariectomized rats. Hesperidin produces free radical scavenging activity in various in vitro antioxidant assays.Formal Name: 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-(2S)-4H-1-benzopyran-4-one. CAS Number: 520-26-3. Synonyms: Cirantin, Hesperidoside, NSC 44184. Molecular Formula: C28H34O15. Formula Weight: 610.6. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.5 mg/ml. lambdamax: 283 nm. SMILES: O=C1C2=C(O)C=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)O3)C=C2O[C@H](C5=CC=C(OC)C(O)=C5)C1. InChi Code: InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1. InChi Key: QUQPHWDTPGMPEX-QJBIFVCTSA-N.