Hesperetin

Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 µM. Hesperetin inhibits IgG-induced beta-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1beta in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.Formal Name: 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 520-33-2. Synonyms: (-)-Hesperetin, (S)-Hesperetin, NSC 57654, (-)-3',5,7-Trihydroxy-4'-methoxyflavanone. Molecular Formula: C16H14O6. Formula Weight: 302.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:8): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 288 nm. SMILES: COc1ccc(cc1O)C1CC(=O)c2c(cc(O)cc2O)O1. InChi Code: InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1. InChi Key: AIONOLUJZLIMTK-AWEZNQCLSA-N. Origin: Plant/Citrus fruits.