Heptelidic acid

Description: Heptelidic acid (Koningic acid) is a sesquiterpenoid lactone antibiotic derived from the probiotic fungus Aspergillus oryzae, a selective GAPDH inhibitor. It downregulates caspase to inhibit etoposide-induced apoptosis. Heptelidic acid inhibits tau fibrillation in a concentration-dependent manner and exerts antitumor effects on extra-intestinal melanoma by controlling glyceraldehyde-3-phosphate dehydrogenase activity. Target: Caspase, Apoptosis, Antibiotic. Smiles: O=C1[C@@]2([C@]3(CO3)CC[C@H](C(C)C)[C@]2(C=C(C(O)=O)CO1)[H])[H]. References: Kim JH, et al. Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells. J Microbiol Biotechnol. 2009 Aug,19(8):787-91.