H-8 (hydrochloride)

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 µM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 µM, respectively.Formal Name: N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide, dihydrochloride. CAS Number: 113276-94-1. Synonyms: Protein Kinase Inhibitor H-8. Molecular Formula: C12H15N3O2S . 2HCl. Formula Weight: 338.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 217, 276, 324 nm. SMILES: CNCCNS(C1=CC=CC2=CN=CC=C21)(=O)=O.Cl.Cl. InChi Code: InChI=1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12,,/h2-6,9,13,15H,7-8H2,1H3,2*1H. InChi Key: RJJLZYZEVNCZIW-UHFFFAOYSA-N.