GW 9662-d5

The peroxisome proliferator-activated receptor gamma (PPARgamma) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs). TZDs are a group of structurally related synthetic PPARgamma agonists with antidiabetic actions in vivo. Rosiglitazone is a prototypical TZD and has served as a reference compound for this class. There are many PPARgamma agonists, including 15-deoxy-Delta12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARgamma-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARgamma antagonist.Formal Name: 2-chloro-5-nitrobenzanilide-10,11,12,13,14-d5. Molecular Formula: C13H4ClD5N2O3. Formula Weight: 281.7. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 35 mg/ml, DMF:PBS(pH7.2) (1:2): >0.5 mg/ml, DMSO: 33 mg/ml, Ethanol: 2 mg/ml. lambdamax: 260 nm. SMILES: ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O. InChi Code: InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)/i1D,2D,3D,4D,5D. InChi Key: DNTSIBUQMRRYIU-RALIUCGRSA-N.