GSK973

A BET BD2 inhibitor (IC50s = 31.62, 15.85, 15.85, and 39.81 nM for BRD2, BRD3, BRD4, and BRDTBD2, respectively), selective for BD2 in BRD2, BRD3, BRD4, and BRDT over BD1 in the same BRDs (IC50s = >10,000 nM for all). Formulation: A solid. InChI: InChI=1S/C23H23FN2O4/c1-25-23(28)15-8-13(22(27)26-20-16-10-29-11-17(16)20)7-14-19(12-5-3-2-4-6-12)18(9-24)30-21(14)15/h2-8,16-20H,9-11H2,1H3,(H,25,28)(H,26,27)/t16-,17+,18-,19+,20+/m1/s1. InChIKey: WZQLVEPIBAOOGF-RMMWZPCPSA-N. SMILES: O=C(C(C=C1[C@@H]2C3=CC=CC=C3)=CC(C(NC)=O)=C1O[C@@H]2CF)N[C@@H]4[C@]5(COC[C@]54[H])[H]