GSK-690

Description: GSK-690 is a selective and potent inhibitor of lysine demethylase 1 (LSD 1), which induces differentiation of leukemic stem cells in acute myeloid leukemia (AML), and can be used in the study of leukemias. Target: Histone Demethylase. Smiles: O(C[C@@H]1CCNC1)C2=CC(=C(N=C2)C3=CC=C(C)C=C3)C4=CC=C(C#N)C=C4. References: Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase J Med Chem. 2017 Oct 12,60(19):7984-7999.