GS-441524

GS-441524
COVID-19 Forschung
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay30469-1 1 mg -

6 - 10 Werktage*

35,00 €
Cay30469-5 5 mg -

6 - 10 Werktage*

61,00 €
Cay30469-10 10 mg -

6 - 10 Werktage*

104,00 €
Cay30469-25 25 mg -

6 - 10 Werktage*

214,00 €
 
GS-441524 is an antiviral nucleoside analog and a metabolite of remdesivir (Cay-30354). Upon... mehr
Produktinformationen "GS-441524"
GS-441524 is an antiviral nucleoside analog and a metabolite of remdesivir (Cay-30354). Upon entry into cells, GS-441524 is metabolized to an active triphosphate form that induces RNA chain termination and inhibits viral polymerases. It is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in infected primary human airway epithelial (HAE) cells (EC50s = 0.86 and 0.18 µM, respectively). GS-441524 reduces viral plaque formation in SARS-CoV-2-infected Vero E6 and Calu-3 2B4 cells (EC50s = 0.42 and 0.62 mM, respectively). It is cytoprotective against hepatitis C virus (HCV), yellow fever virus (YFV), dengue virus type 2 (DENV-2), influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 µM, respectively).Formal Name: 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile. CAS Number: 1191237-69-0. Molecular Formula: C12H13N5O4. Formula Weight: 291.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 247 nm. SMILES: NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@H](O)[C@H](O)[C@@H](CO)O3. InChi Code: InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1. InChi Key: BRDWIEOJOWJCLU-LTGWCKQJSA-N.
Schlagworte: 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
Hersteller: Cayman Chemical
Hersteller-Nr: 30469

Eigenschaften

Anwendung: Antiviral nucleoside analog, active remdesivir metabolite
MW: 291.3 D
Formel: C12H13N5O4
Reinheit: >98%

Datenbank Information

CAS : 1191237-69-0| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H315, H317, H318, H334, H335, H341, H361, H370
P-Sätze: P201, P202, P260, P261, P264, P270, P271, P272, P280, P284, P310, P312, P321, P302+P352, P304+P340, P304+P341, P305+P351+P338, P308+P311, P308+P313, P332+P313, P333+P313, P342+P311, P362+P364, P405, P403+P233, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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