Gomisin J

Gomisin J is a lignan that has been found in Schisandra chinensis and has diverse biological activities. It inhibits HIV-1 IIIB replication in H9 T cells (EC50 = 1.5 µg/ml). Gomisin J (20 µM) decreases LPS-induced increases in nitric oxide (NO) production and p38, ERK, and JNK phosphorylation in RAW 264.7 cells. It induces relaxation of isolated, precontracted endothelium-intact rat aortic rings when used at concentrations of 3, 10, and 30 µg/ml. Gomisin J is cytotoxic to 13 cancer cell lines, including breast, colon, and cervical cancer cells, when used at a concentration of 30 µg/ml.Formal Name: (6R,7S,12aS)-5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-dibenzo[a,c]cyclooctene-3,10-diol. CAS Number: 66280-25-9. Molecular Formula: C22H28O6. Formula Weight: 388.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 215 nm. SMILES: CC1C(C)CC2=C(C(OC)=C(OC)C(O)=C2)C3=C(C=C(O)C(OC)=C3OC)C1. InChi Code: InChI=1S/C22H28O6/c1-11-7-13-9-15(23)19(25-3)21(27-5)17(13)18-14(8-12(11)2)10-16(24)20(26-4)22(18)28-6/h9-12,23-24H,7-8H2,1-6H3. InChi Key: PICOUNAPKDEPCA-UHFFFAOYSA-N. Origin: Plant/Schisandra chinensis.