Gomisin G

Description: Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 µg/mL, therapeutic index: 300). It is a good substrate of CYP2C9. Target: P450, HIV Protease. Smiles: COc1cc2C[C@H](C)[C@](C)(O)[C@@H](OC(=O)c3ccccc3)c3cc4OCOc4c(OC)c3-c2c(OC)c1OC. References: Chen DF, et al. Anti-AIDS agents--XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. Bioorg Med Chem. 1997 Aug,5(8):1715-23.