GNE-8505

GNE-8505 is an inhibitor of dual leucine zipper kinase (DLK). It decreases the levels of phosphorylated JNK in retinal lysates prepared from a mouse model of optic nerve crush when administered at doses of 3, 7, or 18 mg/kg. InChI: InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+ InChIKey: IRPVABHDSJVBNZ-QWHZDKJVSA-N SMILES: NC1=NC=C(C2=NN(CC3CC3)C([C@H]4[C@@]5(CN(C[C@@]54[H])C6COC6)[H])=C2)C=C1C(F)(F)F