Ginsenoside Rg5

Ginsenoside Rg5 is a ginsenoside originally isolated from P. ginseng that has diverse biological activities, including anticancer, anti-inflammatory, neuroprotective, and antioxidant properties. It inhibits the growth of HeLa and MS751 cervical cancer cells (IC50s = ~2.5-10 µM) and induces apoptosis in a concentration-dependent manner. Ginsenoside Rg5 (5 and 10 µM) inhibits LPS-induced increases in IL-1beta, TNF-alpha, COX-2, and inducible nitric oxide synthase (iNOS) protein levels in murine alveolar macrophages. It also inhibits LPS-induced increases in the number of neutrophils and protein levels of IL-1beta, TNF-alpha, COX-2, and iNOS in lung in a mouse model of acute lung inflammation when administered at a dose of 10 mg/kg. In a rat model of Alzheimer's disease induced by streptozotocin (STZ, Cay-13104), ginsenoside Rg5 blocks STZ-induced increases in amyloid-beta accumulation in the hippocampus and cerebral cortex and prevents STZ-induced decreases in step through latency time in a passive avoidance foot-shock test in a dose-dependent manner.Formal Name: (3beta,12beta,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside. CAS Number: 186763-78-0. Molecular Formula: C42H70O12. Formula Weight: 767.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. SMILES: O[C@H]1[C@@]2([H])[C@](CC[C@@H]2/C(C)=C/C/C=C(C)\C)(C)[C@]3(C)CC[C@]4([H])[C@@](CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@@]6([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C4(C)C)(C)[C@@]3([H])C1. InChi Code: InChI=1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10-11,23-38,43-50H,9,12-20H2,1-8H3/b22-11+/t23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+,40+,41-,42-/m1/s1. InChi Key: NJUXRKMKOFXMRX-RNCAKNGISA-N. Origin: Plant/Ginseng Radix et Rhizoma.