Ginsenoside Rb2

Ginsenoside Rb2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities. It inhibits LPS-stimulated increases in vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression in vitro. It dose-dependently reverses LPS-induced decreases in the expression of IkappaBalpha in human umbilical vein endothelial cells (HUVECs). Ginsenoside Rb2 reduces adhesion of THP-1 cells to LPS-stimulated HUVEC cells, also in a dose-dependent manner. Ginsenoside Rb2 reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells. It also lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin (Cay-10010338).Formal Name: (3beta,12beta)-20-[(6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside. CAS Number: 11021-13-9. Synonyms: Ginsenoside C, NSC 308878. Molecular Formula: C53H90O22. Formula Weight: 1079.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@@H](O)CO4)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]5(C)CC[C@]6([H])[C@@](CC[C@H](O[C@]7([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)C6(C)C)(C)[C@@]5([H])C1. InChi Code: InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26-,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-,46-,47-,48-,50-,51+,52+,53-/m0/s1. InChi Key: NODILNFGTFIURN-GZPRDHCNSA-N.