Gingerenone A

Gingerenone A is a diarylheptanoid and polyphenol that has been found in Z. officinale and has diverse biological activities. It inhibits tyrosinase (IC50 = 9.4 µM for the mushroom enzyme) and scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 12.6 µM). Gingerenone A (5 and 10 µM) also inhibits JAK2 and p70 ribosomal S6 kinase 1 (p70S6K1). It selectively decreases the viability of ionizing radiation-induced senescent WI38 fibroblasts over proliferating fibroblasts when used at a concentration of 20 µM. Gingerenone A (50 mg/kg) prevents increases in body weight but does not affect caloric intake in a mouse model of high-fat diet-induced obesity. It decreases tumor weight in an HCT116 colon cancer mouse xenograft model when administered at doses of 5 and 20 mg/kg.Formal Name: 1,7-bis(4E-hydroxy-3-methoxyphenyl)-4-hepten-3-one. CAS Number: 128700-97-0. Molecular Formula: C21H24O5. Formula Weight: 356.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: soluble. lambdamax: 224 nm. SMILES: COC(C=C1CC/C=C/C(CCC2=CC(OC)=C(C=C2)O)=O)=C(C=C1)O. InChi Code: InChI=1S/C21H24O5/c1-25-20-13-15(8-11-18(20)23)5-3-4-6-17(22)10-7-16-9-12-19(24)21(14-16)26-2/h4,6,8-9,11-14,23-24H,3,5,7,10H2,1-2H3/b6-4+. InChi Key: FWDXZNKYDTXGOT-GQCTYLIASA-N. Origin: Plant/Zingiber officinale Roscoe.