Gemcitabine monophosphate

Gemcitabine monophosphate is a monophosphate form of the deoxycytidine analog gemcitabine (Cay-9003096). It has synergistic effects when used in nanoparticle form in combination with cisplatin nanoparticles in vitro at a one-to-one molar ratio (IC50s = 5.95 and 34.8 for the nanoparticle combination and gemcitabine monophosphate alone, respectively). In a stroma-rich mouse xenograft model, the nanoparticle combination of gemcitabine and cisplatin inhibits tumor growth and increases apoptosis.Formal Name: 2'-deoxy-2',2'-difluoro-5'-cytidylic acid. CAS Number: 116371-67-6. Molecular Formula: C9H12F2N3O7P. Formula Weight: 343.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 271 nm. SMILES: [H][C@]1(N2C(N=C(N)C=C2)=O)C(F)(F)[C@H](O)[C@@H](COP(O)(O)=O)O1. InChi Code: InChI=1S/C9H12F2N3O7P/c10-9(11)6(15)4(3-20-22(17,18)19)21-7(9)14-2-1-5(12)13-8(14)16/h1-2,4,6-7,15H,3H2,(H2,12,13,16)(H2,17,18,19)/t4-,6-,7-/m1/s1. InChi Key: KNTREFQOVSMROS-QPPQHZFASA-N.