Gastrodin

Gastrodin is a phenolic glycoside that has been found in Gastrodia and has diverse biological activities. It reduces cell death of rat hippocampal neurons and BV-2 mouse microglia induced by amyloid-beta (1-42) (Abeta42, Cay-20574) and improves learning and memory in various transgenic mouse models of Alzheimer's disease. It reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson's disease induced by 6-OHDA (Cay-25330). Gastrodin (50-200 mg/kg) reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures. In a mouse model of valproic acid-induced autistic-like phenotypes, gastrodin (100 mg/kg) increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and alpha5 subunit-containing GABAA expression in the basolateral amygdala. Gastrodin increases ultimate breaking force and bone stiffness, measures of biomechanical strength, in a rat model of osteoporosis induced by dexamethasone (Cay-11015). It also inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease.Formal Name: 4-(hydroxymethyl)phenyl beta-D-glucopyranoside. CAS Number: 62499-27-8. Molecular Formula: C13H18O7. Formula Weight: 286.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 223 nm. SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(CO)C=C2)O1. InChi Code: InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1. InChi Key: PUQSUZTXKPLAPR-UJPOAAIJSA-N. Origin: Plant/Gastrodia elata.